Curcumin, vitamin D3 & Alzheimer’s

A powerful antioxidant, curcumin has been shown to boost the functioning of the immune system, and many experts strongly believe it may inhibit the build-up of amyloid beta in the brain, the plaques attributed to Alzheimer’s disease. It is also thought to be effective in breaking up existing plaques.

A study at UCLA discovered that curcumin enhanced the binding of amyloid beta to macrophages, which act as the immune system’s “clean-up crew”, traveling through the brain and body and “gobbling up” waste products. In the same study, they found that vitamin D3 strongly stimulated the uptake and absorption of amyloid beta in macrophages.

As an anti-inflammatory, curcumin has also been shown to influence more than 700 genes, and can inhibit the activity and synthesis of cyclooxygenase-2 (COX2) and 5-lipooxygenase (5LOX), as well as other enzymes that cause inflammation. It is well known that Alzheimer’s patients tend to have high levels of inflammation in their brains.

The role of vitamin D3

Research has revealed strong links between low levels of vitamin D3 in Alzheimer’s patients and poor outcomes on cognitive tests.

Medical experts believe that adequate vitamin D3 levels may increase the amount of important chemicals in your brain and protect brain cells.

Like curcumin, vitamin D has anti-inflammatory and immune-boosting capabilities, and sufficient vitamin D is crucial for proper functioning of your immune system to combat inflammation.

What is Curcumin?

Curcumin  is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family.

Curcumin is used extensively in Indian food. It is an integral component of Ayurvedic medicine. The USA has a rate of Alzheimer’s disease four times higher than India. It is postulated that India’s lower rate is due to extensive use of curcumin.

What is Vitamin D3?

Vitamin D3 is an essential nutrient for bone and immune system health. Its main source is sunshine, and it is synthesized through the skin. Deficiencies may occur during winter months or in those who spend a lot of time indoors, such as Alzheimer’s patients.

Along with Bone health, vitamin D is thought to play a role in the prevention of colon, prostate, and breast cancers. A growing body of research also suggests that vitamin D might help prevent and type 1 and type 2 diabetes, hypertension, glucose intolerance, multiple sclerosis, and other medical conditions.

Safety of Curcumin and Vitamin D3

Thankfully, both vitamin D3 and Curcumin are very safe.

Studies of curcumin show that there was no treatment-related toxicity up to 8,000 mg/ day. If you experience stomach upset, nausea or diarrhoea you may need to stop taking it. Consult your doctor if you get these side effects.

Curcumin may not be suitable if you take blood thinning medication such as aspirin or coumadin (warfarin). There are also other drug interactions that you should be aware of.

The vast majority of people are vitamin D deficient and toxicity has only been seen in doses greater than 40,000iu per day (20 times more than in MemoryFix). We advise you to get your level checked to ensure it is adequate. This can be done by requesting a 25-hydroxyvitamin D3 blood test from your doctor. If you have sarcoidosis or other granulomatous diseases, like TB, vitamin D3 may not be suitable for you. Discuss with your doctor before commencing. Do Not take MemoryFix if you are pregnant.